In this work, thermosensitive hydrogels based on N-isopropylacrylamide (NIPAM) and ethylene glycol vinyl ether (EGVE) were synthesized. The hydrogels were prepared by radical copolymerization, and their swelling behavior and temperature sensitivity were investigated. It was found that increasing the EGVE content in the initial monomer mixture led to a higher swelling degree of the hydrogels in water. In addition, increasing the NIPAM content enhanced the thermocollapse behavior of the polymer networks. The interaction of the obtained hydrogels with streptocide was studied, and their potential application as drug delivery carriers and ointment bases was evaluated.